顯微影像核心實驗室

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懇請您將有使用我們設施所發表的期刊與我們分享,請使用者於發表文章時惠予致謝第一共研顯微影像核心,做為服務成效評鑑之用。

有關核心設施之產出涉及智慧財產權之部分如程式設計等,若相關產出對您的期刊發表具重大意義,懇請您將程式設計者列為作者之一。相關的原始碼將在期刊發表之同時,一併上傳至網路分享空間並提供下載路徑供期刊讀覽者下載與引文使用。若未將此部分列入共同作者,該開發程式之智財權仍屬於核心設施與設計者,未來若有其它應用之需求,最一開始提出需求者將不得提出任何智財權之要求。

All users of the Imaging Core Facility should acknowledge the facility in publications and presentations that include data generated in the facility. We also appreciate receiving an electronic version of publications that include data gathered in our facility.

致謝文字參考如下:

We thank the imaging core at the First Core Labs, National Taiwan University College of Medicine, for the technical support in image acquisition and analysis.


煩請將期刊文章PDF檔案寄至:
peggyschsu@ntu.edu.tw

統計區間: 2020/08~2025/8

  1. Liu, C. W., Wang, Y. M., Chen, S. Y., Lu, L. Y., Liang, T. Y., Fang, K. C., Chen, P., Lee, I. C., Liu, W. C., Kumar, A., Kuo, S. H., Lee, J. C., Lo, C. C., Wu, S. C., & Pan, M. K. (2025). The cerebellum shapes motions by encoding motor frequencies with precision and cross-individual uniformity.Nature biomedical engineering, 10.1038/s41551-025-01409-5. Advance online publication.
  2. Tsai, Y. W., Tseng, Y. S., Wu, Y. S., Song, W. L., You, M. Y., Hsu, Y. C., Chen, W. P., Huang, W. H., Chng, J. C., Lim, C. L., Wei, K. H., Ben Lai, S. L., Lee, W. C., & Yang, K. C. (2025). N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes.Nature communications,16(1), 896.
  3. Lin, C. C., Fang, K. C., Balbo, I., Liang, T. Y., Liu, C. W., Liu, W. C., Wang, Y. M., Hung, Y. L., Yang, K. C., Geng, S. K., Ni, C. L., Driscoll, C. P., Ruff, D. S., Kumar, A., Amokrane, N., Desai, N., Faust, P. L., Louis, E. D., Kuo, S. H., & Pan, M. K. (2025). Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients.Science translational edicine,17(787), eadk3922.
  4. Jwo, S. H., Ng, S. K., Li, C. T., Chen, S. P., Chen, L. Y., Liu, P. J., Wang, H. J., Lin, J. S., Ko, C. J., Lee, C. F., Wang, C. H., Ouyang, X., Wang, L., & Wei, T. T. (2025). Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer.Theranostics,15(12), 5890–5908.
  5. Lai, H. J., Kuo, Y. C., Ting, C. H., Yang, C. C., Kao, C. H., Tsai, Y. C., Chao, C. C., Hsueh, H. W., Hsieh, P. F., Chang, H. Y., Wang, I. F., & Tsai, L. K. (2024). Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis.Brain : a journal of neurology,147(12), 4240–4253.
  6. Hsu, C. W., Fang, Y. C., Li, J. F., & Cheng, C. A. (2025). Decoding Complex Biological Milieus: SHINER's Approach to Profiling and Functioning of Extracellular Vesicle Subpopulations.Small (Weinheim an der Bergstrasse, Germany),21(23), e2503638.
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  8. Fu, S. J., Cheng, K. M., Hsiao, C. T., Fang, Y. C., Jeng, C. J., & Tang, C. Y. (2024). Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2.Cell communication and signaling : CCS,22(1), 571.
  9. Huang, Y. Y., Lin, S. J., Chiang, W. Y., Chang, Y. T., Yang, C. C., Liao, C. Y., Chang, Y. L., Lin, C. H., & Teng, S. C. (2025). EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson's disease.NPJ Parkinson's disease,11(1), 157.
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  12. Wu, S. C., Chen, Y. J., Su, S. H., Fang, P. H., Liu, R. W., Tsai, H. Y., Chang, Y. J., Li, H. H., Li, J. C., & Chen, C. H. (2025). Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction.Communications biology,8(1), 105.
  13. Chung, D. J., Wang, C. H., Liu, P. J., Ng, S. K., Luo, C. K., Jwo, S. H., Li, C. T., Hsu, D. Y., Fan, C. C., & Wei, T. T. (2024). Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC.Cancer gene therapy,31(11), 1734–1748.
  14. Hsieh, P. F., Lai, H. J., Kuo, Y. C., Yang, C. C., Huang, P. Y., Ting, C. H., Tai, S. T., Kao, C. H., Tsai, Y. C., Huang, H. W., Shieh, J. Y., Chiou, H., Cheng, L. F., Weng, W. C., & Tsai, L. K. (2025). Mechanisms of functional improvement behind nusinersen treatment in adult spinal muscular atrophy.Experimental neurology,389, 115230.
  15. Jiang, H. H., Wu, T. H., Lee, L. J., Lee, J. C., Chung, B. C., Yang, F. M., & Hu, M. C. (2025). Dendritic Morphology of Developing Hippocampal Neurons in Cyp11a1 Null Mice.Developmental neuroscience,47(3), 157–171.
  16. She, M. P., Hsieh, Y. T., Lin, L. Y., Tu, C. H., Wu, M. S., Hsin, L. W., & Yu, L. C. (2024). Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception.Histology and histopathology,39(7), 903–919.
  17. Chen, H.-Y., Liao, C.-Y., Li, H., Ke, Y.-C., Lin, C.-H., & Teng, S.-C. (2024). ATM-mediated co-chaperone DNAJB11 phosphorylation facilitates α-synuclein folding upon DNA double-stranded breaks.NAR Molecular Medicine,1(2).
  18. Chen, H. Y., Hsieh, W. C., Liu, Y. C., Li, H. Y., Liu, P. Y., Hsu, Y. T., Hsu, S. C., Luo, A. C., Kuo, W. C., Huang, Y. J., Liou, G. G., Lin, M. Y., Ko, C. J., Tsai, H. C., & Chang, S. J. (2024). Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype.Nat Commun,
  19. Chiang, P. T., Tsai, H. H., Yen, R. F., Tsai, Y. C., Wu, C. H., Chiu, C. H., & Tsai, L. K. (2024). In vivo detection of poststroke cerebral cell proliferation in rodents and humans.Ann Clin Transl Neurol,11(2), 497-507.
  20. Dai, Y. C., Yeh, S. Y., Cheng, Y. Y., Huang, W. H., Liou, G. G., Yang, T. Y., Chang, C. Y., Fang, T. F., Chang, C. W., Su, M. T., Lee, C. P., & Chen, M. R. (2024). BGLF4 kinase regulates the formation of the EBV cytoplasmic assembly compartment and the recruitment of cellular IQGAP1 for virion release.J Virol,98(2), e0189923.
  21. Lin, T. C., Tsai, Y. C., Chen, Y. A., Young, T. H., Wu, C. C., Chiang, Y. H., Kao, C. H., Huang, A. P., Hsu, Y. H., Chen, K. Y., & Tsai, L. K. (2023). Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study.Front Cell Neurosci,17, 1170251.
  22. Lin, T. Y., Jiang, D., Chen, W. R., Lin, J. S., Zhang, X. Y., Chen, C. H., Hsu, C. L., Lai, L. C., Chen, P. H., Yang, K. C., Sansing, L. H., & Chang, C. F. (2023). Trained immunity induced by high-salt diet impedes stroke recovery.EMBO Rep,24(12), e57164.
  23. Pai, Y. C., Li, Y. H., Turner, J. R., & Yu, L. C. (2023). Transepithelial Barrier Dysfunction Drives Microbiota Dysbiosis to Initiate Epithelial Clock-driven Inflammation.J Crohns Colitis,17(9), 1471-1488.
  24. She, M. P., Hsieh, Y. T., Lin, L. Y., Tu, C. H., Wu, M. S., Hsin, L. W., & Yu, L. C. (2024). Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception.Histol Histopathol,39(7), 903-919.
  25. Syu, J. J., Chang, C. H., Chang, P. Y., Liu, C. H., Yu, C. J., & Jou, T. S. (2023). Lipid raft interacting galectin 8 regulates primary ciliogenesis.Faseb j,37(12), e23300.
  26. Tsai, S. H., Wu, Y. C., Palomino, D. F., Schroeder, F. C., & Pan, C. L. (2024). Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C.elegans.Cell Rep,43(4), 113996.
  27. Wang, S., Huang, C. H., Lin, T. S., Yeh, Y. Q., Fan, Y. S., Wang, S. W., Tseng, H. C., Huang, S. J., Chang, Y. Y., Jeng, U. S., Chang, C. I., & Tzeng, S. R. (2024). Structural basis for recruitment of peptidoglycan endopeptidase MepS by lipoprotein NlpI.Nat Commun,15(1), 5461.
  28. Wei, S. Y., Chou, Y. H., Chang, F. C., Huang, S. Y., Lai, C. F., & Lin, S. L. (2024). Young Plasma Attenuated Chronic Kidney Disease Progression after Acute Kidney Injury by Inhibiting Inflammation in Mice.Aging Dis.
  29. Yeh, J. Y., Chao, H. C., Hong, C. L., Hung, Y. C., Tzou, F. Y., Hsiao, C. T., Li, J. L., Chen, W. J., Chou, C. T., Tsai, Y. S., Liao, Y. C., Lin, Y. C., Lin, S., Huang, S. Y., Kennerson, M., Lee, Y. C., & Chan, C. C. (2024). A missense mutation in human INSC causes peripheral neuropathy.EMBO Mol Med,16(5), 1091-1114.
  30. ​Chang, F. C., Liu, C. H., Luo, A. J., Tao-Min Huang, T., Tsai, M. H., Chen, Y. J., Lai, C. F., Chiang, C. K., Lin, T. H., Chiang, W. C., Chen, Y. M., Chu, T. S., & Lin, S. L.(2022) Angiopoietin-2 inhibition attenuates kidney fibrosis by hindering chemokine C-C motif ligand 2 expression and apoptosis of endothelial cells.Kidney Int102, 780-797.
  31. Sekar, P., Hsiao, G., Hsu, S. H., Huang, D. Y., Lin, W. W., & Chan, C. M.(2023) Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: Reversing mitochondrial dysfunction and upregulating glyoxalase 1.Redox Biol64, 102786.
  32. Su, Y. H., Wu, Y. Z., Ann, D. K., Chen, J. L. & Kuo, C. Y. (2023) Obesity promotes radioresistance through SERPINE1-mediated aggressiveness and DNA repair of triple-negative breast cancer.Cell Death Dis14, 53.
  33. Lee, Y. M., Chen, Y. H., Ou, D. L., Hsu, C. L., Liu, J. H., Ko, J. Y., Hu, M. C., & Tan, C. T. (2023) SN-38, an active metabolite of irinotecan, enhances anti-PD-1 treatment efficacy in head and neck squamous cell carcinoma.J Pathol259, 428-440, doi:10.1002/path.6055.
  34. Lin, T. C., Tsai, Y. C., Chen, Y. A., Young, T. H., Wu, C. C., Chiang, Y. H., Kao, C. H., Huang, A. P., Hsu, Y. H., Chen, K. Y., & Tsai, L. K. (2023) Brain-derived neurotrophic factor contributes to neurogenesis after intracerebral hemorrhage: a rodent model and human study.Front Cell Neurosci17, 1170251.
  35. Chang, Y. W., Tony Yang, T., Chen, M. C., Liaw, Y. G., Yin, C. F., Lin-Yan, X. Q., Huang, T. Y., Hou, J. T., Hung, Y. H., Hsu, C. L., Huang, H. C., & Juan, H. F. (2023) Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface.Commun Biol6, 427.
  36. Tuan, L. H., Yeh, J. W., Lee, L. J. & Lee, L. J. (2023) Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice.Mol Neurobiol60, 3190-3209.
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  39. Yeh, C. T., Weng, S. C., Tsao, P. N. & Shiao, S. H. (2023) The chaperone BiP promotes dengue virus replication and mosquito vitellogenesis in Aedes aegypti.Insect Biochem Mol Biol155, 103930.
  40. Yu, L. C., Wei, S. C., Li, Y. H., Lin, P. Y., Chang, X. Y., Weng, J. P., Shue, Y. W., Lai, L. C., Wang, J. T., Jeng, Y. M., and Ni, Y. H. (2022) Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses.Cell Mol Gastroenterol Hepatol13, 57-79
  41. Yeh, C. F., Cheng, S. H., Lin, Y. S., Shentu, T. P., Huang, R. T., Zhu, J., Chen, Y. T., Kumar, S., Lin, M. S., Kao, H. L., Huang, P. H., Rosello-Sastre, E., Garcia, F., Jo, H., Fang, Y., and Yang, K. C. (2022) Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo.Sci Adv8, eabl8096
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  43. Kuo, Y. M., Lin, Y. C., Lee, M. J., Chen, J. W., Hsu, C. C., Huang, T. Y., Chen, J. H., Tzeng, S. J., Chiu, Y. L., Wang, S. R., Chia, J. S., Hsieh, S. C., and Jung, C. J. (2022) Biomarker of neutrophil extracellular traps is associated with deep-seated infections and predicts mortality and cardiovascular morbidity in commensal streptococcal bacteremia.J Microbiol Immunol Infect55, 860-869
  44. Hsu, L. F., Chang, B. E., Tseng, K. J., Liao, C. C., Tsai, S. C., Hsiao, H. Y., Lin, S. C., Liao, P. W., Chen, Y. J., and Jane Yao, C. C. (2022) Orthodontic force regulates metalloproteinase-3 promoter in osteoblasts and transgenic mouse models.J Dent Sci17, 331-337
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  46. Chang, W. Y., Yang, Y. T., She, M. P., Tu, C. H., Lee, T. C., Wu, M. S., Sun, C. H., Hsin, L. W., and Yu, L. C. (2022) 5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome.Lab Invest102, 1023-1037
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  50. Wu, C. Y., Jhang, J. G., Lin, W. S., Chuang, P. H., Lin, C. W., Chu, L. A., Chiang, A. S., Ho, H. C., Chan, C. C., and Huang, S. Y. (2021) Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production.iScience24, 103437
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國立台灣大學

分子影像學重點技術平台

醫學院第一共同研究室顯微影像核心

NTU Consortium of Molecular Imaging Key Technology

Imaging Core Facility of the First Core Laboratory, College of Medicine, National Taiwan University

帳務與未繳費而造成無法預約之問題, 請洽R1405 分機288505 李學良先生

A1, M1, ApoTome, Leica SP8, LSM780使用問題, 請洽R1443柯蘊庭副技師 yuntingko@ntu.edu.tw分機288500

LSM880, TIRF/SD, LSM980 使用與影像分析問題, 請洽R1443 羅安琦副技師 anchi0714@ntu.edu.tw 分機288504

HCS, STED, FLIM, Elyra7影像實驗諮詢與影像分析問題, 請洽R1443 許紹君副研究專家 peggyschsu@ntu.edu.tw 分機288509